Bosch is set to showcase its new SVP250 LF processing system for an economic production of injection solutions at this year’s Achema event in Germany.
The event will take place between 11 and 15 June in Frankfurt.
The new flexible processing system has been developed to produce injection solutions (small volume parenterals or SVPs) with small batches ranging from 15 to 250 liters.
Bosch’s new system features both preparation and storage vessel. Depending on the desired volume, the process levels can be extended to four each, in a range of different sizes.
The preconfigured architecture enables to easily install or exchange processing modules, including for different temperature-control concepts or the feeding of different media such as powders, liquids or gases.
Production will also occur at low-oxygen conditions, since the process vessels are installed with a gassing module for nitrogen
For aseptic preparation, the SVP250 LF system is provided with a module between the preparation vessel and storage vessel.
The system is also installed with an optional laminar flow hood that generates a low-turbulence air flow to prevent particles from entering the filling area.
An integrated cleanroom wall completely divides the process vessels from the system’s technical area.
A containment flap is used for applications involving highly potent APIs, while an integrated CIP module cleans and sterilizes the system between production batches.
Bosch subsidiary Pharmatec sales director Dr John Medina said: “Depending on customer preferences, the design allows the system to be expanded with additional process vessels, and modules to be flexibly exchanged.
“Moreover, the vessel’s conical shape minimizes product loss during the emptying process. Given the costly materials the system handles, that translates into a concrete financial benefit.”
The company will also exhibit ALF 5000 filling and closing machine, which can process both ampoules and injection bottles.
ALF 5000 system can be installed all standard filling systems and four, six, eight, ten or twelve filling heads. It can deliver output rates of up to 600 containers per minute.
